Reproductive System and Pregnancy

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Mitochondrial function is fundamental to female reproductive physiology, supporting follicular development, oocyte maturation, and endometrial remodeling. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has recently emerged as a potential contributor to reproductive dysfunctio…

Abstract Background Lactoferrin (LF), a multifunctional glycoprotein of the transferrin family, exhibits anti-inflammatory and immunomodulatory properties. Endometriosis is an estrogen-dependent chronic inflammatory disease commonly treated with progesterone therapy; however, progesterone receptor (PGR) resistance in…

Aim: Recurrent pregnancy loss (RPL) affects approximately 1-2% of women of reproductive age and remains a clinically challenging condition with diverse underlying causes.Inherited thrombophilic abnormalities, particularly Factor V Leiden mutation, have been proposed as potential contributors to its pathogenesis; howev…

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OBJECTIVE: The pathophysiological mechanisms underlying second trimester pregnancy loss are not yet fully elucidated. This study aimed to evaluate whether maternal serum gelsolin levels, together with hematological inflammatory indices and pregnancy related hormones, are associated with second trimester pregnancy loss…

ABSTRACT Purpose To evaluate the association between hysteroscopic treatment of cesarean scar disorder (CSDi), clinical improvement, and changes in the endometrial microbiome, as this remains unclear. Methods This prospective observational study included 40 women diagnosed with symptomatic CSDi. Clinical outcomes, inc…

Objectives: Gestational diabetes is linked to increased inflammatory and metabolic stress during the neonatal period. Among the biomarkers elucidating the relationship between diabetes and inflammation, the interleukin-33 (IL-33)/ST2 signaling pathway is of particular interest. Research on the IL-33/sST2 axis in pregn…

This study investigates the development of innovative, naturally derived therapeutic agents for managing uterine contractions, which have significant implications for tocolysis and dysmenorrhea treatment. Three nano-formulations were evaluated: chemically synthesized gold nanoparticles (CS-AuNPs), green-synthesized go…

Although not a major determinant of receptivity, underexpression of the vitamin D receptor (VDR) is associated with endometrial dysfunction. This study aimed to determine VDR expression in the endometrium of patients with recurrent implantation failure (RIF) and unexplained infertility (UEI) using polymerase chain rea…

Background/Aim: Early differentiation of partial hydatidiform mole from missed abortion remains challenging because clinical and ultrasonographic findings may overlap during the first trimester. The contribution of systemic inflammatory response to this diagnostic process is unclear. This study aimed to compare inflam…

Pregnancy management in women with primary immunodeficiencies (PIDs) is an increasing clinical focus due to improved life expectancy. However, evidence guiding optimal maternal immunoglobulin G (IgG) levels to ensure favorable outcomes is limited, with no consensus on therapeutic targets. This study aimed to evaluate…