Orthopedic Infections and Treatments

Background/Objectives: Alignment philosophy in total knee arthroplasty (TKA) may affect joints beyond the knee. Mechanical alignment (MA) targets a neutral mechanical axis, whereas kinematic alignment (KA) aims to restore native alignment and joint line obliquity (JLO). This study compares the effects of MA and KA on…

Implant-associated infections remain a major challenge due to biofilm formation and uncontrolled antibiotic release from conventional coatings. This study presents an enzyme-responsive nanoparticle-based coating designed to enable localized and on-demand antibiotic delivery on titanium implant surfaces. Hyaluronidase-…

Staphylococcus epidermidis is a major cause of periprosthetic and other implant-associated orthopedic infections because of its ability to adhere to biomaterial surfaces and form biofilm. Tranexamic acid (TXA) is routinely used in arthroplasty to reduce perioperative blood loss; however, emerging evidence suggests tha…

BACKGROUND: Periprosthetic joint infection (PJI) following total knee arthroplasty remains a serious complication associated with substantial morbidity and complex surgical management. Two-stage revision arthroplasty is widely accepted as the gold standard treatment, in which an antibiotic-loaded cement spacer is used…

PURPOSE: adhesion and assess the biocompatibility of provisional crown materials using real-time cell analysis. MATERIALS AND METHODS: < .05). RESULTS: < .001). Cell viability showed a time-dependent pattern, with the highest values in the VSO group at 24 h and in the DPO group at 72 h. CONCLUSION: adhesion, and highe…

Objective: This study aimed to compare retrograde intramedullary nailing (RIMN) and femoral locked plating (FLP) in the management of periprosthetic supracondylar femur fractures (PSFF) following total knee arthroplasty (TKA), focusing on fracture healing, blood loss, functional outcomes, and complication rates.Method…

Bridge plate fixation performed using a minimally invasive technique, the main fracture fragments are stabilised along the anatomical axis, rather than reducing small fragments, particularly in comminuted fractures. This retrospective study aims to evaluate the clinical and radiographic outcomes of stabilising traumat…

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Introduction: Diabetic foot infections (DFIs) remain a significant clinical problem despite advances in the treatment of diabetes mellitus.This study aims to contribute to the body of knowledge in this field by evaluating the epidemiological characteristics, treatment processes, and outcomes of patients diagnosed with…

BACKGROUND: Wet cupping therapy (Hijama) is a widely practiced procedure in traditional medicine. When performed under non-sterile conditions, it can lead to severe infections. In this report, we present a case of sacroiliac abscess and osteomyelitis that developed following cupping therapy. CASE PRESENTATION: A 35-ye…

This study compared the effects of systemic Levofloxacin and Cephalexin on bone healing in a rat tibial fracture model. The subjects were divided into six groups (n=7 each): healthy control, fracture control, healthy Levofloxacin, healthy Cephalexin, fractured Levofloxacin, and fractured Cephalexin. In total, 42 Sprag…

Background/Objectives: Implant-associated infections are challenging conditions in orthopedic surgery. This experimental study aimed to evaluate phage localization within infected tissues following different routes of administration. Methods: An implant-related infection model was created using methicillin-resistant S…