Hemophilia Treatment and Research

Abstract Inhibition of Coagulation Factor X (FXa) is a clinically validated therapeutic strategy; however, developing safer and more selective inhibitors remains a major challenge. In this study, we developed an interpretable machine learning–based QSAR framework to predict both the inhibitory potency and activity cla…

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INTRODUCTION: Haemophilic arthropathy (HA) impairs joint health, walking capacity, and postural balance in adults with haemophilia (AwH). Evidence regarding the combined effects of manual therapy and structured exercise on postural balance remains limited. AIM: To investigate the effects of manual therapy combined wit…

Musculoskeletal complications remain common in people with severe hemophilia A (PwsHA) despite advances in medical treatment. Joint damage, pain, and functional limitations may affect health-related quality of life (QoL). This study aimed to evaluate QoL in PwsHA and examine associations of joint health, pain severity…

Introduction: This study aimed to evaluate whether ChatGPT provides satisfactory responses to frequently asked questions (FAQs) about joint health and physiotherapy approaches for patients with hemophilia.Methods: Fifty questions were reviewed by five expert physiotherapists, who selected the 10 FAQs.Responses were ge…

ABSTRACT Introduction Postural balance may be affected in adults with haemophilia (AwH). Studies report decreased dynamic balance (DB), but results of static balance (SB) are contradictory in AwH. The causes of DB impairment and its associated parameters are underexplored. Aim To examine SB and DB, and relationship of…

OBJECTIVE: Apheresis is a medical procedure used to remove harmful blood components across different disciplines. This bibliometric analysis evaluated the scientific characteristics of the 100 most-cited articles (T100) with the term "apheresis" in the title published between 1975 and 2025. MATERIALS AND METHODS: Data…

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INTRODUCTION: Hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH) has a substantial impact on patients' health-related quality of life (HRQoL). While generic instruments are frequently used for assessment, they may not fully capture the disease-specific burden. This study aimed to evaluate HRQoL in patien…

Introduction: Hereditary Angioedema (HAE) is a rare genetic disorder characterized by recurring episodes of submucosal and subcutaneous edema, posing significant physical, emotional, and psychological challenges to patients' well-being.Purpose: This study aims to explore the experiences of adolescents and young adults…

Aim: Hemophilia is an X-linked hereditary coagulation disorder characterized by recurrent bleeding episodes that significantly impair patients’ quality of life. This study aimed to evaluate the quality of life levels of pediatric patients with hemophilia and their parents according to clinical variables such as diseas…

Hipertansiyon hemodiyaliz tedavisi alan hastalarda görülen kronik komplikasyonlardan birisidir. Etkin yönetilemediği zaman kardiyovasküler hastalıklara neden olmaktadır. Hastalığın kronik hemodiyaliz tedavisi alan hastalarda yönetimi ile ilgili kanıta dayalı rehberler sınırlı sayıdadır. Bu rehberlere göre, hastalığın…

Hemodiyaliz tedavisi alan hastalarda aşırı duyarlılık reaksiyonları nadir görülmelerine karşın hayati tehlikesi olan reaksiyonlardır. Son dönem böbrek yetmezliği olan hasta popülasyonunun prevalansı düşünüldüğünde bu tür reaksiyonların sonuçlarının ciddiyeti de önem kazanmaktadır. Potansiyel maruziyetlerin çokluğu, ma…