Peroxisome Proliferator-Activated Receptors

Pipecolic acid (PA) is an important biomarker associated with peroxisomal and neurological disorders, necessitating the development of rapid, selective, and cost-effective detection methods beyond conventional chromatographic techniques. In this study, a molecularly imprinted electrochemical sensor (PA-MIP/Au) was dev…

Abstract Background Hypertension is a leading cause of cardiovascular disease and all-cause mortality. In addition, owing to the pathological processes it causes in the vascular bed, it leads to end-organ damage, thereby contributing to morbidity. FABP3 (fatty acid binding protein 3) is a protein primarily expressed i…

Supplementary Material 1.

Supplementary Material 1.

Özet henüz yok.

Introduction: Studies have demonstrated that insults during development increase the risk for developing diseases later in life, including hypertension, ischemic heart disease, stroke, respiratory disease, diabetes, cancer, as well as psychiatric disorders. Hence, as mitochondrial dysfunction-induced oxidative stress…

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Özet henüz yok.

Abstract In this study, a new series of nimesulide-derived ureas (3a–j) was designed and synthesized to investigate structural modifications of nimesulide and to evaluate their biological activity. The compounds were obtained in high yields (68–88%) under organotin-catalyzed conditions, and their structures were unequ…

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Metabolic diseases are characterized by a complex interplay between metabolic dysregulation and chronic low-grade inflammation. Fetuin-A (FetA), a liver-derived hepatokine, has emerged as a key mediator linking these processes through its pro-inflammatory and insulin resistance–promoting effects. Accumulating evidence…

Metabolic inflammation, a state of chronic low-grade inflammation linked to insulin resistance, plays a central role in the development of obesity-related conditions such as type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disorders. In recent years, two molecules have gained significant…