Liver physiology and pathology

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The liver is an important organ that participates in the body’s chemical composition regulation, among which are detoxification, energy storage, and protein and lipid metabolism activities. These functions are important for metabolic control. Nevertheless, several other causes, including poisoning agents, drugs, and a…

Abstract Objectives Cholestasis, characterized by impaired bile flow and bile accumulation, leads to progressive liver injury largely mediated by oxidative stress. Taurine, a conditionally essential amino acid with antioxidant and cytoprotective properties, may protect against cholestatic liver damage. This study inve…

BACKGROUND: Glutamate dehydrogenase (GDH) levels are known to be important in predicting the development of complications associated with liver disease. AIM: In this study, we aimed to investigate the relationship between GDH activity and liver fibrosis grades, APRI, AAR, FIB-4 and AFP levels in patients with viral he…

DEN-CDHFD–treated miR-146a female mice have an increased proportion of CCL5-expressing dysfunctional CD8 T cells and an aberrant monocyte population according to scRNA-seq. A, UMAP displaying annotated cell clusters revealed by scRNA-seq using mouse livers. B, The levels of a T cell and monocyte cluster in 2-month-old…

Abstract Aberrant HGF–c-MET signaling is a major driver of hepatocellular carcinoma (HCC) progression and a clinically validated therapeutic axis, but current inhibitors predominantly target the intracellular kinase domain and remain vulnerable due to limited selectivity and resistance development. We therefore pursue…

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INTRODUCTION: Advanced non-squamous non-small cell lung cancer (NSCLC) remains associated with substantial mortality despite major advances in targeted therapy and immuno-oncology. c-Met protein overexpression represents a biologically relevant and relatively prevalent phenotype that may define a therapeutically vulne…

Background and Aim: methylation levels, integrated within machine learning algorithms, for non-invasive staging of hepatic fibrosis in patients with MASLD, and to compare its performance against established non-invasive biomarkers. Materials and Methods: Patients with biopsy-proven MASLD and healthy controls were recr…

Aspartame, a widely used artificial sweetener, has raised concerns regarding its potential hepatotoxicity under chronic exposure. This study aimed to investigate the protective roles of phenylboronic acid (PBA) and exosomes (Exo) againist chronic aspartame-induced liver injury in male BALB/c mice through modulation of…

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