Advanced Drug Delivery Systems

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• İZZET KARAHAN
• MURAT ÇELEBİ

Neurodegenerative diseases represent a major global health challenge due to their progressive nature and lack of curative therapies. Developing innovative strategies to protect and regenerate neuronal structures is therefore crucial. In recent years, Sobetirome, a synthetic thyromimetic compound, has emerged as a prom…

Objectives: this study aimed to develop and optimize an intranasal delivery system for Eplerenone (EPL) by incorporating Eplerenone-loaded liposomes (Elip) into an in situ gel system (Elip-GG). The goal was to prolong the residence time of the drug in the nasal cavity and ensure sustained release. Methods: Elip and un…

The delivery of protein and peptide therapeutics presents substantial challenges due to their inherent instability, vulnerability to enzymatic degradation, and low bioavailability. Nanoparticle-based delivery systems offer promising solutions, providing protection, controlled release, and targeted delivery for these t…

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Vascular Endothelial Growth Factor (VEGF) is a critical factor in pathological neovascularization, making it the primary target for ocular anti-angiogenic therapies. Anti-VEGF treatments suffer from requiring frequent intraocular injections for effective treatment due to limited half-life. This study aimed to utilize…

Vascular Endothelial Growth Factor (VEGF) is a critical factor in pathological neovascularization, making it the primary target for ocular anti-angiogenic therapies. Anti-VEGF treatments suffer from requiring frequent intraocular injections for effective treatment due to limited half-life. This study aimed to utilize…

Nanoparticles have been used as promising carriers for targeted and controlled drug delivery by researchers due to their unique physicochemical properties, such as size, surface charge, and especially shape. Among these parameters, the shape of nanoparticles has attracted increasing attention because it significantly…

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Objective: This study aimed to comparatively evaluate the antimicrobial activity of free salicylic acid, liposomal salicylic acid, and an arbutin-containing liposomal salicylic acid formulation against Cutibacterium acnes (C. acnes), a key microorganism in the pathogenesis of acne vulgaris, and to assess the contribut…

Psoriasis is a chronic, inflammatory, and immune mediated dermatological diseases that adversely affects the quality of life of millions of individuals worldwide. Due to its heterogeneous natüre, which varies from patient to patient, and its systemic manifestations, current treatment approaches are often insufficient…

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