Prostate Cancer Treatment and Research

Aim: This study aimed to analyze the challenges encountered during the transition from open retropubic radical prostatectomy (RRP) to laparoscopic radical prostatectomy (LRP) at a long-standing center of open RRP experience and to evaluate surgical, tumor-related, and functional outcomes during the adaptation period.M…

Accumulation of Variants of Uncertain Significance (VUS) in DNA Damage Response (DDR) genes creates a bottleneck for patient selection in early-phase trials. While BRCA-mutated tumors have established therapies, ATM and PALB2 VUS carriers often remain ineligible for PARP inhibitors. We aimed to reclassify germline VUS…

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ABSTRACT Prostate‐specific membrane antigen (PSMA) is overexpressed in over 90% of prostate cancer tumors, making it a strong target for imaging and therapy. The diagnostic tracer [ 18 F]F‐Piflufolastat provides high affinity and image quality, while the β‐emitter [ 177 Lu]Lu‐PSMA‐617 enables targeted treatment. Despi…

5112 Background: Previously, we proposed novel risk group definitions for prostate cancer patients based on Prostate-Specific Membrane Antigen (PSMA) targeted positron emission tomography (PET). PSMA-PET pan-stage nomograms (PPP3) were developed using the international, multicentre PROMISE registry (NCT06320223) to pr…

SUMMARY: The underlying causes of many diabetes-related complications are well known. However, the reasons for the complication related to male reproductive health remain unclear. Hyperglycemia disrupts the balance between oxidants and antioxidants, causing damage to cells, especially ER stress. ER stress triggered by…

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OBJECTIVE: Ga-PSMA-11 PET/CT is promising for characterizing tumor biology. The 5-point PRIMARY score, which considers uptake, focality, and location, has limited data on predicting occult high-grade cancer in GG1 biopsy patients. This study assessed the score's accuracy in predicting upgrading in GG1 prostate cancer…

PURPOSE: The prognostic value of the PSA ELIMination rate constant K (KELIM PSA) score was investigated in patients with metastatic castration-sensitive prostate cancer (mCSPC) treated with docetaxel in combination with ADT. METHODS: This multicenter retrospective study included 105 patients diagnosed with prostate ad…

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Background Body mass index (BMI) has been associated with improved outcomes in several malignancies, including prostate cancer. However, the impact of BMI on treatment efficacy, particularly with androgen receptor pathway inhibitors (ARPIs), in metastatic hormone-sensitive prostate cancer (mHSPC) remains insufficientl…

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