Neuroscience and Neuropharmacology Research

According to quantum chromodynamics, at sufficiently high energy, the structure of hadrons reveals a dynamic equilibrium between gluon splitting and gluon recombination-a phenomenon known as saturation. The process of diffractive photonuclear production of a J/ψ vector meson provides a direct insight into the gluon co…

Amaç:Bu çalışmanın amacı, Na⁺-K⁺-2Cl⁻ kotransporter-1 (NKCC1) inhibitörü olan bumetanidin (BMT), pentilentetrazol (PTZ) ile indüklenen epileptiform hücresel hasara karşı olası nöroprotektif etkisini ve bu etkinin oksidatif stres parametreleri ile ilişkisini HT-22 nöronal hücre hattında araştırmaktır.Yöntem:HT-22 hücre…

Acetylcholinesterase is one of the key enzymes responsible for the hydrolysis of acetylcholine at cholinergic synapses. Inhibition of AChE activity may contribute to an increase in acetylcholine levels in the synaptic cleft and to the enhancement of cholinergic neurotransmission. Therefore, AChE inhibitors are conside…

Acetylcholinesterase is one of the key enzymes responsible for the hydrolysis of acetylcholine at cholinergic synapses. Inhibition of AChE activity may contribute to an increase in acetylcholine levels in the synaptic cleft and to the enhancement of cholinergic neurotransmission. Therefore, AChE inhibitors are conside…

Patients with cerebrovascular disease frequently require concomitant antiplatelet and antiseizure therapy. However, experimental evidence regarding potential pharmacodynamic interactions between these medications remains limited. The present study investigated whether clopidogrel affects the anticonvulsant effects of…

Oxidative stress and apoptosis contribute to seizure-associated neuronal injury, but the effects of ML-171, a pharmacological NOX-1 inhibitor, on PTZ-associated oxidative and apoptotic injury remain insufficiently defined. This study evaluated the effects of the NOX-1 inhibitor ML-171 in pentylenetetrazole (PTZ)-induc…

Amaç: Bu çalışma, subkonvülsif pentilenetetrazol (PTZ) ile indüklenen deneysel absans epilepsi modelinde kronik nöbet stresi sonucu ortaya çıkan kardiyak iyon kanallarındaki (HCN2 ve CACNA1G) patolojik değişiklikleri ve NZF2b çinko parmak proteininin ekspresyonunu araştırmayı ve eksojen çinkonun bu moleküler tablo ve…

PurposeThis study aimed to systematically assess ictal scalp electroencephalography (EEG) evolution by examining both ictal onset characteristics and late significant patterns (LSPs) in adults with focal epilepsy. We aimed to investigate their individual and collective descriptive roles in seizure lateralization and l…

The molecular programs coordinating inhibitory interneuron migration, maturation, and survival during forebrain development remain incompletely understood. Here we investigate ARHGEF6, a RAC1/CDC42 guanine nucleotide exchange factor linked to X-linked intellectual disability (XLID46) and previously studied only at pos…

The molecular programs coordinating inhibitory interneuron migration, maturation, and survival during forebrain development remain incompletely understood. Here we investigate ARHGEF6, a RAC1/CDC42 guanine nucleotide exchange factor linked to X-linked intellectual disability (XLID46) and previously studied only at pos…

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