T-cell and B-cell Immunology

Deficiency of dedicator of cytokinesis 8 (DOCK8) is a combined immunodeficiency characterized by severe atopic dermatitis, recurrent infections, and elevated serum immunoglobulin E (IgE) levels. Following genetic confirmation, early hematopoietic stem cell transplantation (HSCT) is the treatment of choice. We report a…

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The novel allele HLA-C*12:05:03 differs from HLA-C*12:05:01 by one nucleotide change G>T in exon 5 (GTG>GTT). The findings presented in this poster were previously reported as a novel allele and published in HLA: Immune Response Genetics.

Caspase recruitment domain-containing protein 9 (CARD9) deficiency is a rare primary immunodeficiency characterized by a profound susceptibility to invasive fungal infections. Given its significant phenotypic overlap with hyper-IgE syndrome (HIES)—most notably, markedly elevated serum IgE levels—misdiagnosis remains a…

Background and aim: Antithymocyte globulin (ATG) therapy is conventionally monitored by measuring peripheral blood CD3+ T-cell counts. However, CD3+ T-cell quantification requires flow cytometry and may not be routinely available in centers. This study aimed to identify clinical and laboratory predictors of CD3+ T-cel…

This repository contains the comprehensive dataset, raw data sheets, and histological findings supporting the manuscript titled "Ectopic Thymogenesis within Lymph Nodes Induces Donor-Specific Central Tolerance in a Rat Allotransplantation Model". The study investigates the temporal dynamics and structural outcomes of…

This repository contains the comprehensive dataset, raw data sheets, and histological findings supporting the manuscript titled "Ectopic Thymogenesis within Lymph Nodes Induces Donor-Specific Central Tolerance in a Rat Allotransplantation Model". The study investigates the temporal dynamics and structural outcomes of…

Multiple sclerosis is a chronic immune-mediated central nervous system disorder marked by neuroinflammation, demyelination, and neurodegeneration, and effectively modeled by experimental autoimmune encephalomyelitis. The objective of this study was to elucidate the roles of T follicular helper and T follicular regulat…

Predicting major histocompatibility complex class II (MHC-II)–restricted epitopes is challenging; however, AlphaFold (AF) may provide a structure-based pan-prediction solution. In this study, we have established the new tool AF-prediction (AF-pred) with a clear standard for quantitative prediction results of MHC-II–re…

Background/Objectives: Promoter DNA methylation is conventionally summarised as a regional mean. Two alternatives have been proposed to capture information the mean discards: the concurrence ratio derived from partially methylated bisulfite reads (CAMDA) and single-CpG Shannon (β-) entropy. Benchmarks of such metrics…

Objective: Type 1 Diabetes Mellitus (T1DM) is an autoimmune condition characterized by progressive pancreatic β-cell destruction, with high familial clustering rates. Siblings of index cases with T1DM represent a critical population for understanding immunogenetic mechanisms, as they share genetic backgrounds while de…

Objective: The HLA system exhibits significant population variability due to demographic history. As a migration crossroad, Turkiye has a complex genetic structure. This study analyzes 25 years of data from a single center in West-Central Anatolia to document the evolution of regional HLA distribution between low-migr…