ANTICARCINOGENIC EFFECTS OF AVOCADO AND PEANUT ON HUMAN PROSTATE (PC3) AND LUNG CANCER (A459) CELLS

Türkçe

Objective: In recent years due to their natural ingredients phytotherapeutic sources have become increasingly needed as alternatives to chemotherapeutic drugs. Avocado and peanut were shown to contain diverse bioactive compounds exhibit anti-oxidant, anti-inflammatory and anti-proliferative effects. We aimed to determine and compare the anticarcinogenic effects of Bacon and Fuerte avocado, Osmaniye peanuts on the inhibition the viability of human prostate carcinoma (PC3) and human lung carcinoma (A549) cells. Methods: Three kilograms of avocados and peanuts were purchased domestically produced. Avocados and peanuts were divided into three parts. Avocado and peanut parts were dissolved in 96% and 60% ethanol. A549 and PC3 cells were incubated with 200μg/ml ethanol extracts of avocados and peanuts for 24 hours. PC3 and A549 cancer cell viability analysis was performed using CCK-8 Kit. Results: All parts of Bacon and Fuerte avocado were cultured with A549 and PC3 cells caused decrease in the viability of both cancer cells. All parts of peanut caused decrease in viability of A549 but there was no difference for PC3. Also, the peel and seed parts in 96% ethanol of Bacon and Fuerte avocado caused more decrease than pulp part for A549 and PC3. The inner peel and kernel parts in 96% ethanol of peanut caused more decrease than outer peel part for A549 but there was no difference for PC3. Conclusion: Peel and seed parts of avocados and outer sheel and kernel parts of peanuts can serve as valuable sources to reduce cancer cell viability.