Makale detayı · 2023
An efficient microwave‐assisted synthesis of novel quinolone–triazole and conazole–triazole hybrid derivatives as antimicrobial and anticancer agents
Journal of Heterocyclic Chemistry
- Yıl
- 2023
- ISSN
0022-152X- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Abstract 1,2,4‐Triazole‐fluoroquinolone and 1,2,4‐triazole–conazole hybrids are designed, synthesized, and investigated in vitro against a variety of common diseases. The structure of the newly synthesized compounds are characterized from spectral data (IR, 1H NMR, 13C NMR, and LC–MS). The antibacterial activity against both Gram‐positive and Gram‐negative bacteria is shown to be enhanced by many of the produced compounds. Also, some of the products are found to have strong antiproliferative effects aganist HeLa cervical cancer cells, whilst demonstrating cytotoxic effects toward normal cells.
Konular
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
Birincil konu Cancer therapeutics and mechanisms