Parietal Cortex Volume and Functions in Major Depression and Bipolar Disorder: A Cloud-Based Magnetic Resonans Imaging Study

OpenAlex İngilizce

Parietal Lobe (PL) has been increasingly studied to elucidate the etiology of psychiatric diseases in recent years (1).As a part of adaptive control, PL was associated with cognitive functions of major cognitive, attention and work memory regions (2).Several studies analyzed the functions and the anatomy of PL in mood disorders (MD).Neurocognitive tests demonstrated that working memory, visuospatial attention and problem-solving ability deteriorated during the manic period, and episodic memory deteriorated during the depressive period in bipolar disorder (BD) (3).Atypical functional cerebral asymmetry and impairment in visuospatial attention were identified in the right frontoparietal lobe during the euthymic period in BD patients (4,5).The deterioration in visual-spatial planning in BD and major depressive disorder (MDD) was associated with low parietal activity.Studies conducted with functional magnetic resonance imaging (fMRI) demonstrated that this deterioration was more common in MDD and BD patients when compared to healthy individuals, and it was more prevalent in BD patients when compared to the MDD patients (6).The correlations between PL and attention and working memory have been emphasized in several studies.The results of the selective attention tests conducted in these studies suggested that the right frontal and parietal regions were associated with selective attention; and thus, BD (2,7,8).Similarly, it has been known that the posterior parietal lobe was associated with attention and memory, and these parameters were significantly different in MDD and BD patients when compared to healthy individuals (9). Conclusion:The present study findings demonstrated that BD and MDD patients in remission exhibited lower PL volume and CT performance when compared to healthy controls, emphasizing that PL could be structurally and functionally significant in the pathophysiology of mood disorders.