Premenopozal ve postmenopozal kadınlarda lipit profili ve plazma aterojenik indeksinin karşılaştırılması

Türkçe

Objective: Menopause leads to changes in hormonal status, metabolism and lipid profile.The aim of the present study was to determine the influence of menopause and age on lipid profile in women.Methods: This study included 160 postmenopausal and 260 premenopausal healthy women.Serum lipid profile including total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and atherogenic index of plasma (AIP) were estimated.Premenopausal women were further arranged in to two different age group of 22-45 years and above 45 years of age.The premenopausal and postmenopausal women were recruited and classified using a comprehensive questionnaire.Results: There were statistically significant increases in TC, LDL-C, TG and AIP but there was no significant difference in HDL-C level between premenopausal and postmenopausal women.Only LDL-C level was significantly increased in premenopausal women above 45 years of age compared with the premenopausal women between 22-45 years of age.Conclusion: Menopause alters lipid profile.Atherogenic index of plasma which is a marker of plasma atherogenicity may be used to asses risk of developing atherosclerosis in postmenopausal women.