Role of Augmenter of Liver Regeneration on Testicular Ischemia and Ischemia/Reperfusion Injury: An Experimental Study

OpenAlex İngilizce

A BSTRACT Background: Testicular torsion causes ischemic injury, and torsion causes reperfusion injury. Aim: Evaluating the role of augmenter of liver regeneration (ALR) in testicular ischemia and ischemia/reperfusion injury. Materials and Method(s): Seventy-eight (78) healthy Wistar albino male rats were randomly divided into four groups; control (C) ( n = 6), sham (S) ( n = 24), torsion (T) ( n = 24), and torsion/detorsion (T/D) ( n = 24). S, T, and T/D groups were divided into four subgroups ( n = 6) as 1 st , 2 nd , 3 rd , and 4 th hours. Blood, tissue ALR, and histology analyses were performed between groups and subgroups. Results: The increase in plasma ALR values at the 3 rd and 4 th hours compared to the 1 st hour in the T group were significant ( P < 0.01, P < 0.001, respectively). In the T/D group, a significant increase was observed in plasma ALR values at the 3 rd and 4 th hours compared to the 1 st hour ( P < 0.05, P < 0.001, respectively). Plasma ALR values at the 1 st , 2 nd , 3 rd , and 4 th hours were higher in the T and T/D groups than in the C group ( P < 0.001, P < 0.05, respectively). Plasma ALR values were higher in the T group at the 1 st , 2 nd , 3 rd , and 4 th hours than in the S group ( P < 0.05). A significant increase was observed in tissue ALR at the 3 rd and 4 th hours than at the 1 st hour in the T group ( P < 0.05, P < 0.001, respectively). A significant increase was observed in tissue ALR at the 3 rd and 4 th hours than in the 1 st hour in the T/D group ( P < 0.05, P < 0.001, respectively). Discussion: ALR in plasma and testicular tissue has a potential role in the early diagnosis of testicular torsion and in predicting the prognosis of T and T/D.