Makale detayı · 2021
Etodolac nanosuspension based gel for enhanced dermal delivery: in vitro and in vivo evaluation
- Yıl
- 2021
- ISSN
0265-2048- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Aim The objective of this study was to develop dermal nanosuspension (NS) based gel formulation of etodolac (ETD).Methods Etodolac nanosuspension (ETD-NS) was prepared by wet milling method and dispersed in hydroxypropyl methylcellulose (NS-HPMC) or hydroxyethyl cellulose (NS-HEC) gels. Rheologic and mechanical properties were investigated. In vitro and ex vivo permeability studies were performed. Topical anti-inflammatory and analgesic activity were evaluated in regard to carrageenan-induced inflammatory paw oedema and radiant heat tail-flick method, respectively.Results The ETD-NS with approximately 190 nm particle size (PS), 0.16 polydispersity index (PDI), and −15 mV zeta potential (ZP) values were obtained. The work of bioadhesion values of NS-HEC and NS-HPMC gels were 0.229 mJ/cm2 for both gels. Dermal permeation of ETD from NS-HEC gel (7.18%) was found significantly higher than the NS-HPMC gel (4.56%). Enhanced anti-inflammatory and analgesic activity of NS-HEC gels were observed in comparison with micronised ETD.Conclusions ETD-NS based gel formulation is promising for topical delivery of ETD.
Konular
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Oral microbiology and periodontitis research
Birincil konu Advancements in Transdermal Drug Delivery