Long Term Growth Hormone Therapy in a Patient with IGF1R Deletion Accompanied by Delayed Puberty and Central Hypothyroidism

OpenAlex İngilizce

What is already known on this topic: Insulin-like growth factor-1 (IGF-1) is the main driver of growth during prenatal life.Patients with IGF1R defects exhibit variable phenotypic features.The most common symptom is pre-and postnatal growth retardation, followed by microcephaly, developmental delay, facial dysmorphism and extremity anomalies.rhGH has been used in patients with IGF1R defects with variable treatment responses What this study adds: Long-term rhGH with an early onset may have more beneficial effects in terms of induction of growth.Regarding the complex physiological effects of IGF1, patients should be followed for hormone deficiencies such as hypogonadism and hypothyroidism.