Makale detayı · 2004
Synthesis and Antioxidant Properties of Novel Benzimidazole Derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry
- Yıl
- 2004
- ISSN
1475-6374- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Some novel benzimidazole derivatives carrying thiosemicarbazide and triazole moieties at the N1 position were synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels determined by measuring the formation of 2-thiobarbituric acid reactive substance. The free radical scavenging properties of the compounds were also examined in vitro by determining the capacity to scavenge superoxide anion formation and the interaction with the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). The compounds showed a significant effect in the above tests except to scavenge superoxide anion formation.
Konular
- Synthesis and biological activity
- Free Radicals and Antioxidants
- Synthesis of Organic Compounds
Birincil konu Synthesis and biological activity