Makale detayı · 2005 · article
Synthesis and antioxidant properties of novel benzimidazoles containing substituted indole or 1 1 4 4 tetramethyl 1 2 3 4 tetrahydro naphthalene fragments
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- YÖKSİSYÖKSİS makale kaydı
- YÖKSİS dergi adıJournal of Enzyme Inhibition and Medicinal Chemistry
- Katalog eşleşmesi (ISSN)Journal of Enzyme Inhibition and Medicinal Chemistry
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- Semantic Scholaratıf sayısı (OpenAlex ile birleştirilmez)
Özet
Some 6-fluoro-5-substituted-benzimidazole derivatives in which indole and 1,1,4,4-tetramethyl-1,2,3,4-tetrahydro-naphthalene groups were attached to the 2-position of the benzimidazole ring were synthesized and tested for antioxidant properties in vitro. Almost all the synthesized compounds at the 10(-3) M concentrations showed superoxide anion scavenging activity. Compounds 5, 3, 9, 4, 17 and 13 have strong inhibitory effects on superoxide anion formation (98%, 93%, 91%, 88%, 85% and 81%, respectively) at 10(-3) M concentration and these results are better than 30 IU of superoxide dismutase (SOD) (76%). Compound 11 is the most effective scavenger of 2,2-diphenyl-1-picrylhydrazyl (DPPH) stable free radical at 10(-3)M (61%) concentration.
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