Assessment of the Inflammatory Markers in Patients with First-episode Psychosis: A Comparative Study

OpenAlex · İngilizce

Objective: Recently, the importance of inflammatory processes in the etiology of psychotic disorders has been increasingly emphasized.The manner in which the inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR), are affected during psychotic disorders is unknown.This study aimed to compare the NLR, MLR, and PLR levels between patients with first-episode psychosis (FEP), patients with chronic psychotic disorder (CPD) and healthy controls (HC).Methods: This study included 36 patients with FEP, 57 patients with CPD, and 93 HC.The Kruskal-Wallis test was used for intergroup comparisons of inflammatory markers.Linear regression analysis was used to examine the extent to which the NLR levels were affected by age.Results: The NLR levels of patients diagnosed with CPD were higher than those diagnosed with FEP and HC.There was no difference between the NLR levels of patients with FEP and HC.Even after removing the age effect between the groups, there was a significant difference between the groups in terms of the NLR levels.However, there was no intergroup difference in the MLR and PLR levels.Conclusion: Higher NLR levels in patients with CPD than in patients with FEP and HC indicated that the inflammatory process was increased in psychotic disorders during the prognosis of the chronic disease.To further understand the underlying causes of psychotic disorder, additional longitudinal studies are required to identify the manner, in which inflammatory processes are impacted by the disorder.