Evaluation of Acute Phase Response in Blood and Milk Samples of Healthy Holstein Cattle in the Postpartum Period

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Normally, birth triggers an acute phase response (APR).In particular, interleukins and proinfl ammatory cytokines released from activated leukocytes at the site of tissue damage stimulate APR.In the liver, these cytokines also stimulate acute phase proteins (APPs).APPs are one of the options used in monitoring the health status of animals.This study was evaluated in 12 healthy Holstein cattle, 3-6 years old, who calved at least once.Blood and milk samples were collected from the animals' immediately after calving (0 th h) and on the 7 th , 14 th , and 21 st days postpartum.Haptoglobin (Hp), serum amyloid A (SAA), ceruloplasmin (Cp), milk amyloid A (MAA), albumin, total protein (TP) and globulin levels were determined in blood serum and milk serum samples.In the findings; when the measurements of blood and milk Hp, Cp and SAA and TP values were compared; there was a statistically significant diff erence (P<0.05) between 0 th h and 21 st day measurements.In the correlation findings, a relationship was found between APP's in blood and milk.In conclusion, this study revealed that APR develops after calving and in the postpartum 21-day period, and the developing APR can clearly be seen in blood and milk.In addition, it was shown that the APR can be traced from milk in dairy cattle, in the present study.