Makale detayı · 2015 · article
Synthesis of platinum II complexes of 2 cycloalkyl substituted benzimidazoles and their cytotoxic effects
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- YÖKSİS dergi adıZeitschrift für Naturforschung
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Özet
Five novel Pt(II) complexes with some 2-cycloalkyl-substituted benzimidazole carrier-ligands were synthesized and evaluated for their in vitro cytotoxic activities against HeLa and OVCAR-3 cell lines. A cell viability test revealed that [dichloro-bis(2-cycloheptylbenzimidazole) platinum(II)] is less cytotoxic than cisplatin, and its cytotoxic effect can be compared with that of carboplatin. Flow cytometric analysis revealed that this complex at 117 μM concentration causes apoptosis in approx. 72 % of the OVCAR-3 cell population. In addition, the complex was found to cause an increase in the SubG1 population of both OVCAR-3 and HeLa cells and to cause less apoptosis in HeLa cells than cisplatin.
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Yerel katalogda bu makaleye atıf yapan 2 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- 2026 Design, synthesis, and biological evaluation of platinum(II) complexes bearing chiral 2-(1-hydroxyethyl)benzimidazole ligands as potential anticancer agentsAtıf 0 · OpenAlex
- 2026 SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NEW PLATINUM (II) COMPLEXES BEARING SUBSTITUTED BENZIMIDAZOLE LIGANDSAtıf 0 · OpenAlex