Farelerde 3-Metilkolantren ile İndüklenen Fibrosarkoma Üzerine Sisteaminin Etkileri

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Understanding the biology, developing methods for prevention and treatment of tumors is of great importance. The present study was investigated protective effects of the cysteamine on 3-methylcholantrene-induced fibrosarcoma in mice. In the experiment, white male mice (Mus musculus albino) were used approximately 20±2.0 g in weight. Divided into five groups, per group of 15 mice and were fed ad libitum with a standard diet and water. No drug was performed in the first group of animals. Sesame oil (0.2 ml volume) for the second group of mice were injected subcutaneously. The third group was given in drinking water 0.1% solution of cysteamine (ad libitum). 3-methylcholantrene solution (1 mg/0.2ml sesame oil) were injected for the fourth group of mice subcutaneously with 0.2 ml volume. The five group was performed 0.2 ml volume of 3-methylcholantrene solution (1 mg/0.2 ml sesame oil) subcutaneously and 0.1% dissolved in water was ad libitum disintegrating orally. Animals were observed for 4 months. The mice that euthanasiaded cervical dislocation were autopsied at the end. Morphological changes in organs and tissue samples taken from tumor formation was investigated with histopathological methods. In conclusion ıt is suggested that cysteamine has a protective effect on 3-methylcholantrene-induced fibrosarcoma in mice.