CIRCULATING MICRORNA-101-3P AND MICRORNA-21-5P AS NON-INVASIVE BIOMARKERS IN THE DIAGNOSIS, RISK, PROGNOSIS AND SURVIVAL OF LARYNX CANCER

İngilizce (OpenAlex)

ABSTRACT Introduction: To evaluate the effects of circulating microRNA-21-5q (miR-21) and microRNA-101-3p (miR-101) values on diagnosis, prognosis and survival in laryngeal squamous cell carcinoma (LSCC). Methods: Forty-six patients with LSCC and 30 healthy volunteers were included. Patients’ peripheral blood samples were analyzed for miR-21 and mir-101 and evaluated their relationship with prognostic factors for LSCC. Results: The fold change between the two groups was examined and found that miR-21 expression in the patient group was 1,708 times upregulated while miR-101 expression was found to be 0.675 times down-regulated. In the patient group, miR-21 expression with clinicalT (p=0.001), clinical stage (p=0.023), pathologicalT (p=0.002), pathological stage (p=0.006), lymphatic invasion (p=0.009) and cartilage invasion (p=0,011) was found statistically significant weak positive correlation. In the risk analysis, it was found that if miR-101 is greater than the cut-off value, it has been found to increase the disease risk by 5.20 times. Conclusions: miR-21 may be an important biomarker in the diagnosis and follow-up of LSCC. miR-101 expression can be a potential prognostic factor in LSCC. Key words: Larynx cancer, miRNA-101-3p, miRNA-21-5p, survival, prognosis Key Points Inorder to predict patient prognosis and miRs are promising novel biomarkers. There is a positive correlation of miR-21 with the prognostic features. Higher serum levels of miR-21 can predict lower five-year survival rate. miR-101 expression was found related with pN. miR-101 cut-off value raised the disease risk by 5.20 times