The effect of Hippomarathrum microcarpum Petrov (Apiaceae) growing in Turkey on PC3 cancer cell proliferation

Türkçe

Apiaceae is the 3rd largest family of Turkey with the largest genus, which is widely distributed throughout the world and represented in our country with 109 genera and 450 species. The genus Hippomarathrum has 28 species which are outspread in the North, Northwest, West and Central of Iran, Turkey, Caucasus and Iraq and one of this species H. microcarpum Petrov is a plant which grows wild in Turkey and is used as food by the people in Eastern Anatolia. In this study, the in vitro anticancer activity of the aqueous and ethanol extracts obtained from H. microcarpum was investigated on cancer cell proliferation. For this purposehuman prostate (PC-3) cells were used and measurements were performed via MTT test. Aqueous and ethanol extracts obtained from aerial parts exhibited potent inhibitor effects on cell proliferation. Ethanol extract inhibited the proliferation of PC-3 cell at 24th hour with a 12.99 mg/mL IC50 value