Oxidative stress and inflammation in breast cancer: Mechanistic interactions and clinical implications

İngilizce (OpenAlex)

The development and progression of breast cancer (BC) are influenced by genetic, hormonal, and metabolic factors, as well as by signals within the tumor microenvironment. A review of studies on BC biology and treatment outcomes was undertaken. The studies were experimental, translational, and clinical, and were indexed in PubMed and Web of Science. The focus was on the connection between oxidative and inflammatory markers and clinical endpoints, as well as intervention strategies that modify these pathways. Oxidative stress and inflammation promote tumor growth, metastasis, and immune evasion by driving various biological activations. New data suggest that biomarkers could enhance BC assessment, but strategies are limited. Inflammation and oxidative stress are closely connected processes in BC and may offer important opportunities for therapy. In the future, research should combine molecular studies with clinical trials to improve our understanding of this interaction and determine its clinical value for prognosis and treatment.