NMR and DSC studies on the reactions of pentanedioxy spiro-ansacyclochlorotriphosphazene and pentanedioxy triple-bridgedcylochlorotriphosphazene with monofunctional nucleophiles

OpenAlex İngilizce

In this study, the reactions of 2-(2-hydroxyethyl) thiophene (2) and benzyl alcohol (3) withpentanedioxycyclochlorotriphosphazene (1) and pentanedioxy triple-bridged cylochlorotriphosphazene (6)were studied. The novel cyclotriphosphazene compounds: two di-substituted spiro-ansa, N 3 P 3 [O(CH 2 ) 5 O]-(C 6 H 7 OS)] 2 (4) and N 3 P 3 [O(CH 2 ) 5 O-(C 6 H 5 CH 2 O)] 2 (5); and two fully substituted triple-bridged,N 3 P 3 [O(CH 2 ) 5 O] 3 -(C 6 H 7 OS) 6 N 3 P 3 (7) and N 3 P 3 [O(CH 2 ) 5 O] 3 -(C 6 H 5 CH 2 O) 6 N 3 P 3 (8) derivatives wereformed in THF solvent by using NaH base at ambient conditions. Because of their variety of applications,there is a great deal of interest in the preparation of aromatic macrocyclic derivatives of cyclophosphazenes.The main purpose of these studies is to develop bioactive cyclophosphazene derivatives in the search fornew effective drug candidates for the treatment of various diseases, in particular, anticancer andantimicrobials. The synthesized compounds (4, 5, 7, 8) were defined using analytical techniques namelyElement analysis, TLC/MS system, and NMR spectroscopy. Thermal stabilities, crystal purity, andrecrystallization properties and corresponding enthalpies of synthesized derivatives were analyzed in thecourse of heating and cooling cycles of DSC.