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Makale detayı · 2015

Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

Dergi

PLoS ONE
OpenAlex Açık erişim · gold SJR Q1 JCR Q1 Atıf 189 Üst %10 Yüzdelik 96.2% FWCI 5.33
Yıl
2015
DOI
10.1371/journal.pone.0122686
Tür
article

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  • YÖKSİS dergi adı PLoS ONE
  • OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)

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Özet

OpenAlex · İngilizce

BACKGROUND: Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. METHODS: Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS. RESULTS: In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P<0.001,). Females had a reduced risk of secondary progressive MS (HR (95% CI) = 0.77 (0.67 to 0.90) P = 0.001). In primary progressive MS (n = 1,373), there was a significant increase in EDSS over time in males and females (P<0.001) but there was no significant sex effect on the annualized rate of EDSS change. CONCLUSION: Among registrants of MSBase, male relapse-onset patients accumulate disability faster than female patients. In contrast, the rate of disability accumulation between male and female patients with primary progressive MS is similar.

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189 atıf

OpenAlex cited_by_count (önbellek / veritabanı)

Yerel katalogda bu makaleye atıf yapan 19 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).

  1. Defining secondary progressive multiple sclerosis 2016 Atıf 423 · OpenAlex
  2. Early clinical markers of aggressive multiple sclerosis 2020 Atıf 63 · OpenAlex
  3. First-year treatment response predicts the following 5-year disease course in patients with relapsing-remitting multiple sclerosis 2025 Atıf 7 · OpenAlex
  4. First-year treatment response predicts the following 5-year disease course in patients with relapsing-remitting multiple sclerosis 2025 Atıf 7 · OpenAlex
  5. Early clinical markers of aggressive multiple sclerosis 2019 Atıf 7 · OpenAlex
  6. Determinants of disability development in patients with multiple sclerosis 2021 Atıf 6 · OpenAlex
  7. Determinants of therapeutic lag in multiple sclerosis 2021 Atıf 6 · OpenAlex
  8. Multiple Sclerosis Severity Score (MSSS) improves the accuracy of individualized prediction in MS 2022 Atıf 4 · OpenAlex
  9. Multiple Sclerosis Severity Score (MSSS) improves the accuracy of individualized prediction in MS 2022 Atıf 4 · OpenAlex
  10. Comparative Efficacy and Safety of Extended Versus Standard Interval Dosing of Natalizumab in Relapsing–Remitting Multiple Sclerosis Patients: A Multicenter Analysis 2025 Atıf 3 · OpenAlex

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