Makale detayı · 2024
Effect of Propofol Induction on Antioxidant Defense System, Cytokines, and CD4+ and CD8+ T Cells in Cats
Kafkas Universitesi Veteriner Fakultesi Dergisi
- Yıl
- 2024
- ISSN
1300-6045- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
We investigated the effects of propofol on the antioxidant defense mechanisms, pro and anti-inflammatory cytokine expressions and specific defense processes in the study since these parameters play a significant role in postoperative complications, regulation of immune reactions, and wound healing.Twenty male cats were included in the study, anesthesia protocol was induced by IV administration of 6 mg/kg of propofol.Blood samples were harvested right before (T0) and fifteen minutes after (T1) propofol injection.Serum malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), IL-4, IL-8, TNF-α, IL-1β, and IFN-γ levels; the number of CD4+, CD8+ T cells and CD4/CD8 ratio in peripheral blood were determined.Propofol reduced the serum MDA and GSH-Px, while CAT and SOD levels remained unchanged.Furthermore, propofol did not impact serum IL-8, TNF-α, and IL-1β levels.Contrastingly, IFN-γ level tended to elevate, and serum IL-4 level was significantly increased.On the other hand, the CD8+ T cell population was significantly decreased, while the number of CD4+ T cells and the CD4/CD8 ratio were unaffected.Briefly, propofol did not adversely affect oxidative defense mechanisms, proinflammatory and anti-inflammatory cytokine cascade, and cell mediated immunity.Considering the insufficiency of cats' hepatic drug metabolism, we may conclude that propofol is a safe product regarding the investigated parameters.
Konular
- Cancer, Stress, Anesthesia, and Immune Response
- Anesthesia and Neurotoxicity Research
- Neuropeptides and Animal Physiology
Birincil konu Cancer, Stress, Anesthesia, and Immune Response