Makale detayı · 2015
Identification of Susceptibility Loci in IL6 RPS9 LILRB3 and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome Wide Association Study
Dergi
ARTHRITIS RHEUMATOLOGYISSN 2326-5205
ISSN kaydı başka bir dergiye işaret ediyor; ad YÖKSİS kaydından.
- Yıl
- 2015
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı ARTHRITIS RHEUMATOLOGY
- Katalog eşleşmesi (ISSN) Arthritis and Rheumatology
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
OBJECTIVE: Takayasu arteritis is a rare large vessel vasculitis with incompletely understood etiology. This study was undertaken to perform the first unbiased genome-wide association analysis of Takayasu arteritis. METHODS: Two independent cohorts of patients with Takayasu arteritis from Turkey and North America were included in our study. The Turkish cohort consisted of 559 patients and 489 controls, and the North American cohort consisted of 134 patients and 1,047 controls of European ancestry. Genotyping was performed using the Omni1-Quad and Omni2.5 genotyping arrays. Genotyping data were subjected to rigorous quality control measures and subsequently analyzed to discover genetic susceptibility loci for Takayasu arteritis. RESULTS: We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)). The genetic susceptibility locus in RPS9/LILRB3 lies within the leukocyte receptor complex gene cluster on chromosome 19q13.4, and the disease risk variant in this locus correlates with reduced expression of multiple genes including the inhibitory leukocyte immunoglobulin-like receptor gene LILRB3 (P = 2.29 × 10(-8)). In addition, we identified candidate susceptibility genes with suggestive levels of association (P < 1 × 10(-5)) with Takayasu arteritis, including PCSK5, LILRA3, PPM1G/NRBP1, and PTK2B. CONCLUSION: Our findings indicate novel genetic susceptibility loci for Takayasu arteritis and uncover potentially important aspects of the pathophysiology of this form of vasculitis.
Konular
Atıflar
OpenAlex cited_by_count. WoS veya Scopus atıf sayısı değildir; o kaynaklar için ayrı kolon yoktur.
105 atıf
OpenAlex cited_by_count (önbellek / veritabanı)
Yerel katalogda bu makaleye atıf yapan 14 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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- Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study 2023
- Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study 2021
- Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study 2021
- Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study 2021
- Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study 2021
- Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study 2021
- Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study 2021
- Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study 2021