İçeriğe geç
akaturk Akademik ölçüm
Giriş yap Kayıt ol

Makale detayı · 2013

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

Dergi

Science
OpenAlex SJR Q1 JCR Q1 Atıf 527 Üst %1 Yüzdelik 99.8% FWCI 23.97
Yıl
2013
DOI
10.1126/science.1231897
Tür
article

Veri kaynağı ayrımı

  • YÖKSİS dergi adı Science
  • OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)

OpenAlex kaydı

Özet

OpenAlex · İngilizce

The initial phase in the development of a migraine is still poorly understood. Here, we describe a previously unknown signaling pathway between stressed neurons and trigeminal afferents during cortical spreading depression (CSD), the putative cause of migraine aura and headache. CSD caused neuronal Pannexin1 (Panx1) megachannel opening and caspase-1 activation followed by high-mobility group box 1 (HMGB1) release from neurons and nuclear factor κB activation in astrocytes. Suppression of this cascade abolished CSD-induced trigeminovascular activation, dural mast cell degranulation, and headache. CSD-induced neuronal megachannel opening may promote sustained activation of trigeminal afferents via parenchymal inflammatory cascades reaching glia limitans. This pathway may function to alarm an organism with headache when neurons are stressed.

Konular

Atıflar

OpenAlex cited_by_count. WoS veya Scopus atıf sayısı değildir; o kaynaklar için ayrı kolon yoktur.

527 atıf

OpenAlex cited_by_count (önbellek / veritabanı)

Yerel katalogda bu makaleye atıf yapan 45 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).

  1. Hallmarks of primary headache: part 1 – migraine 2024 Atıf 192 · OpenAlex
  2. Inadequate brain glycogen or sleep increases spreading depression susceptibility 2018 Atıf 89 · OpenAlex
  3. Behçet Disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger 2017 Atıf 89 · OpenAlex
  4. Inadequate Brain Glycogen or Sleep Increases Spreading Depression Susceptibility 2017 Atıf 89 · OpenAlex
  5. Inadequate Brain Glycogen or Sleep Increases Spreading Depression Susceptibility 2017 Atıf 89 · OpenAlex
  6. Shared Fate of Meningeal Mast Cells and Sensory Neurons in Migraine 2019 Atıf 77 · OpenAlex
  7. Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion 2019 Atıf 75 · OpenAlex
  8. Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion 2019 Atıf 75 · OpenAlex
  9. Parenchymal neuroinflammatory signaling and dural neurogenic inflammation in migraine 2021 Atıf 71 · OpenAlex
  10. Brain glycogen metabolism: A possible link between sleep disturbances, headache and depression 2021 Atıf 54 · OpenAlex

Yazarlar

Yazar bilgisi yok.