Makale detayı · 2007
The Diagnostic Value of TTF-1, CK 5/6, and p63 Immunostaining in Classification of Lung Carcinomas
Dergi
Applied immunohistochemistry & molecular morphology- Yıl
- 2007
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS dergi adı Applied immunohistochemistry & molecular morphology
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
This study was aimed to evaluate the utility of a panel of antibodies, consisting of thyroid transcription factor-1 (TTF-1), p63, and cytokeratins (CK) 5/6 for distinguishing between small cell lung carcinoma (SCLC) and nonsmall cell lung carcinoma, as well as for identifying glandular or squamous differentiation in small tissues obtained by bronchoscopy. Bronchoscopic biopsies of 77 lung carcinoma cases with easily recognizable morphologic features were included in this study. All the cases were immunohistochemically stained for p63, CK5/6 [indicators of squamous cell carcinoma (SCC)] and TTF-1 [indicator of SCLC and adenocarcinoma (AC)]. Although, 28 SCLC displayed TTF-1 positive, p63 negative immunoprofile, most of the SCC (32/39) had the opposite immunoprofile. All of the 10 ACs were negative for p63 and most of them (8/10) were negative for CK5/6. p63 and CK 5/6 seem to be useful for differentiating AC and SCLC from SCC with 100% specificity and 82% sensitivity, 89% specificity and 79% sensitivity, respectively. It seems that to achieve histologic typing of lung cancer as accurate as possible, TTF-1 in combination with p63 and CK 5/6 might be useful components of immunohistochemical analysis of poorly differentiated lung carcinomas in biopsy tissues.
Konular
Atıflar
OpenAlex cited_by_count. WoS veya Scopus atıf sayısı değildir; o kaynaklar için ayrı kolon yoktur.
181 atıf
OpenAlex cited_by_count (önbellek / veritabanı)
Yerel katalogda bu makaleye atıf yapan 11 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Bibliometric Analysis of Turkey’s Research Activity in the Anatomy & Morphology Category from the Web of Science Database 2021
- A Bibliometric Analysis of Turkey's Research Activity in the Anatomy and Morphology Category from the Web of Science Database 2021
- Bibliometric Analysis of Turkey's Research Activity in the Anatomy and Morphology Category from the Web of Science Database 2021
- The value of cytokeratin 5 6 p63 and thyroid transcription factor 1 in adenocarcinoma squamous cell carcinoma and non small cell lung cancer of the lung 2015
- Potential utility of p63 expression in differential diagnosis of non small cell lung carcinoma and its effect on prognosis of the disease 2014
- Potential utility of p63 expression in differential diagnosis of non-small-cell lung carcinoma and its effect on prognosis of the disease 2014
- Potential utility of p63 expression in differential diagnosis of non small cell lung carcinoma and its effect on prognosis of the disease 2014
- Expression of p63 ttf 1 and maspin in non small cell lung carcinoma and their effect on the prognosis and differential diagnosis 2015
- Expression of p63 ttf 1 and maspin in non small cell lung carcinoma and their effect on the prognosis and differential diagnosis 2015
- Expression of p63 ttf 1 and maspin in non small cell lung carcinoma and their effect on the prognosis and differential diagnosis 2015