Makale detayı · 1997
Histopathologic Effects of Mitomycin-C on Endoscopic Transnasal Dacryocystorhinostomy
Dergi
Ophthalmic surgery, lasers & imaging retina- Yıl
- 1997
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS dergi adı Ophthalmic surgery, lasers & imaging retina
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
BACKGROUND AND OBJECTIVES: The antimetabolite mitomycin-C is now being used in endoscopic transnasal dacryocystorhinostomies to prevent the closure of osteotomies. PATIENTS AND METHODS: A 0.5-mg/ml solution of mitomycin-C was applied to the osteotomy site for 2 1/2 minutes intraoperatively. Specimens from four patients were collected during surgery and at 15 days, 1 months, 3 months, and 6 months after surgery. The specimens were examined under light and electron transmission microscopy and were compared with control specimens. RESULTS: Light microscopy showed attenuated epithelium with intracytoplasmic vacuoles. Subepithelial connective tissue was looser and hypocellular. Electron microscopy confirmed these findings and demonstrated swelling of mitochondria, dilatation of endoplasmic reticulum, and chromatin-dense granules in nuclei of fibroblasts. CONCLUSION: By causing a decrease in density and cellularity of mucosa, topical use of mitomycin-C may enhance the success of surgery; however, further studies are necessary to determine the ultimate potential of this agent for this procedure.
Konular
Atıflar
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75 atıf
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Yerel katalogda bu makaleye atıf yapan 10 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Adjunctive use of mitomycin C on endoscopic lacrimal surgery 1998
- Adjunctive use of mitomycin C on endoscopic lacrimal surgery 1998
- Long-term results of adjunctive use of mitomycin C in external dacryocystorhinostomy 2007
- Diode laser-assisted endoscopic dacryocystorhinostomy: a comparison of three different combinations of adjunctive procedures 2013
- Diode laser assisted endoscopic dacryocystorhinostomy a comparison of three different combinations of adjunctive procedures 2013
- Use of adjunctive mitomycin C in external dacryocystorhinostomy surgery compared with surgery alone in patients with nasolacrimal duct obstruction: A prospective, double-masked, randomized, controlled trial 2009
- Comparison of transcanalicular diode laser dacryocystorhinostomy and external dacryocystorhinostomy in patients with primary acquired nasolacrimal duct obstruction 2014
- Topical application of mitomycin C prevents epineural scar formation in rats 2005
- Topical application of mitomycin C prevents epineural scar formation in rats 2004
- Efficacy of adjunctive mitomycin C in transcanalicular diode laser dacryocystorhinostomy 2017