Makale detayı · 2020
Asymmetric Synthesis of Chiral γ‐ and δ‐Amino Esters Using Trichlorosilane Activated with a Lewis Base Catalyst
- Yıl
- 2020
- ISSN
2365-6549- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Abstract Novel chiral γ‐ and δ‐ amino esters 2 a – k were synthesized by enantioselective reduction of N ‐aryl γ‐ and δ‐imino esters with aryl, substituted aryl, and heteroaryl groups 1 a – k using trichlorosilane activated with optically active N ‐pivaloyl L ‐proline I in high yields (50%–98%) with enantioselectivities (10%–84% enantiomeric excess). The structures of the chiral amino esters 2 a – k were clarified by infrared, nuclear magnetic resonance ( 1 H and 13 C) and gas chromatography‐mass spectrometry. The enantiomeric excess of these compounds were identified by chiral high‐performance liquid chromatography using a Chiralpak AD−H column. The highest ee of 84% and highest yield of 98% were found for 2 d .
Konular
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
Birincil konu Asymmetric Synthesis and Catalysis