Makale detayı · 2018
Serum paraoxonase activity and total sialic acid in sheep with foot and mouth disease
Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice
- Yıl
- 2018
- ISSN
0025-8628- DOI
- 10.21521/mw.6078
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
The aim of this study was to investigate paraoxonase (PON1) activity and total sialic acid to be measured for the first time in sheep infected naturally with foot and mouth disease, and their relationships with oxidative stress. A total of 30 Awassi sheep (aged between 2–4), which were healthy and infected with the foot and mouth disease virus (FMDV) were used in the study. Concentrations of paraoxonase activity (PON1), which is an important antioxidant against oxidative stress, high density lipoprotein (HDL) and total sialic acid (TSA), which has a critical role for immune system and is one of the significant indicators of cellular degeneration, were measured in serum samples drawn from animals. The total oxidant capacity (TOC) and total antioxidant capacity (TAC) were evaluated to determine the oxidative balance. It was observed that serum PON1 (P<0.001) and HDL (P<0.01) concentrations were significantly lower compared to the control group. TSA concentration was higher in the infected group (P<0.001) compared to the healthy group. TOC was higher (P<0.001) and TAC was lower (P<0.01) in the infected group compared to the control group. Consequently, harmful effects of the infection of foot and mouth disease were shown as cause of oxidative cell damage and the high rate of sialic acid was produced depending on the degeneration during the infection. .
Konular
- T-cell and Retrovirus Studies
Birincil konu T-cell and Retrovirus Studies