Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report

İngilizce (OpenAlex)

A Case Report Brugada syndrome is an inherited arrhythmogenic disease that may cause sudden cardiac death due to ventricular fibrillation in young adults.Brugada syndrome is usually identified by a characteristic type 1 electrocardiography (ECG) pattern that consists of ST elevation of a coved type in the precordial leads V 1 to V 3 .In addition, the term Brugada phenocopy is used to describe conditions that induce Brugada-like ECG manifestations in patients without true Brugada syndrome.Some drugs and conditions can cause a Brugada type 1 ECG pattern which is not true congenital Brugada syndrome (1,2).Propafenone (Rythmol, Abbott, Chicago, IL, USA) is a group 1C antiarrhythmic drug that has sodium channel-blocking effects.Excessive intake may cause severe arrhythmias such as bradycardia, sinoatrial block, atrioventricular block, intraventricular block, junctional and/or ventricular tachycardia, or chaotic ventricular rhythm (3-7).Intoxication with class I antiarrhythmic drugs is associated with a higher mortality rate (22.5%) than other drugs (1%) (3).We present a case report of successful treatment of Brugada phenocopy due to propafenone intoxication. CASE PRESENTATIONA 15-year-old girl was admitted to the emergency room with complaints of vomiting and loss of consciousness lasting 3 hours.Upon admission, her blood pressure was 70/45 mmHg, her heart rate was 60/minute, and the body temperature was 36.8 °C.The initial ECG revealed sinus rhythm, absent of