Makale detayı · 2021
Molecular modelling studies to suggest novel scaffolds against SARS-CoV-2 target enzymes
YÖKSİS
OpenAlex
Açık erişim · diamond
SJR Q3
TR Index
Atıf 1
Yüzdelik 52.3%
FWCI 0.13
- Yıl
- 2021
- DOI
- 10.29228/jrp.96
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Journal of Research in Pharmacy
- Katalog eşleşmesi (ISSN) Journal of Research in Pharmacy
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
In this study, molecular modelling study of previously synthesized compounds against SARS-CoV-2 target enzyme was performed. A subset of 156 compounds from an in-house database has been subjected to molecular modelling studies against the SARS-CoV-2 ADP-ribose phosphatase (ADRP, NSP3), Papain-like protease (PL pro ), and uridine specific endoribonuclease (NSP15) enzymes. We have identified one compound that is expected to inhibit the SARS-CoV-2 ADRP enzyme and one compound that is expected to inhibit the NSP15 enzyme.
Konular
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
Birincil konu Computational Drug Discovery Methods