Makale detayı · 2006
Lipid peroxidation in liver tissue of ovariectomized and pinealectomized rats: effect of estradiol and progesterone supplementation
Dergi
Cell Biochemistry and Function- Yıl
- 2006
- DOI
- 10.1002/cbf.1313
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS dergi adı Cell Biochemistry and Function
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
The present study aimed to determine the effect of estradiol-progesterone supplementation and pinealectomy on lipid peroxidation of liver tissue in ovariectomized rats. The study was carried out on 36 adult Sprague-Dawley female rats, which weighed 200-250 g. The rats were divided into 6 groups: Group 1: Sham Ovariectomy (Sham-Ovx), Group 2: Ovariectomy (Ovx), Group 3: Ovx + Estradiol-Progesterone supplementation (Ovx + H), Group 4: Sham Pinealectomy and Ovx (Sham Pnx -Ovx), Group 5: Ovx -Pnx, Group 6: Ovx -Pnx + H. Malondialdehyde (MDA), reduced form of glutathione (GSH) and glutathione peroxidase (GSH-Px) levels were determined in liver tissue of rats. The highest MDA levels and the lowest GSH-Px levels were determined in the ovariectomized-pinealectomized group, whereas the lowest MDA was in the Sham-Ovx group, and the highest GSH-Px levels were found in the Sham-Ovx and Ovx + Hormone supplemented group. Furthermore, the highest GSH levels were in group 1 and lowest levels were in group 5. The findings of this study demonstrate that ovariectomy led to lipid peroxidation in liver tissues of rats. Pinealectomy in addition to ovariectomy, increases lipid peroxidation, but, estradiol and progesterone supplementations to the ovariectomized-pinealectomized rats protect against lipid peroxidation to a significant extent.
Konular
Atıflar
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Yerel katalogda bu makaleye atıf yapan 36 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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- The Effects of Diabetes and or Polymicrobial Sepsis on the Status of Antioxidant Enzymes and Pro Inflammatory Cytokines on Heart Liver and Lung of Ovariectomized Rats 2011
- The Effects of Diabetes and or Polymicrobial Sepsis on the Status of Antioxidant Enzymes and Pro Inflammatory Cytokines on Heart Liver and Lung of Ovariectomized Rats 2011
- The Effects of Diabetes and or Polymicrobial Sepsis on the Status of Antioxidant Enzymes and Pro Inflammatory Cytokines on Heart Liver and Lung of Ovariectomized Rats 2011
- The Effects of Diabetes and or Polymicrobial Sepsis on the Status of Antioxidant Enzymes and Pro Inflammatory Cytokines on Heart Liver and Lung of Ovariectomized Rats 2011