Investigation of the Effects of Three Different Generations of Fluoroquinolone Derivatives on Erythrocyte Fragility and Hematological Parameters in Rats

OpenAlex İngilizce

Objektive: Fluoroquinolones (FQs) are synthetic broad-spectrum antimicrobial agents derived from nalidixic acid. They are used in the treatment of urinary tract infections, respiratory tract infections, skin infections, digestive system infections, genital infections and other bacterial infections. Although the relationship between FQs and oxidative stress has been demonstrated, their effects on erythrocyte fragility have not been adequately studied. In this study, the effects of three different FQ derivatives (ciprofloxacin (CIP), levofloxacin (LVX) and moxifloxacin (MXF)) on erythrocyte fragility and hematological parameters were investigated in rats at the end of the 1st, 7th and 14th day treatments. Material and Method: 72 Wistar albino male rats were divided into 4 groups with 18 rats in each group and sacrificed at three different time points (1st, 7th and 14th days). Results: A significant increase in 0.2% sodium chloride (NaCl) concentration erythrocyte fragility value was found in the MXF group on 1st day compared to the control group on 1st day. While the FQ derivatives used in the study did not cause a general change on the erythrocyte and leukocyte parameters, they caused various fluctuations on the platelet parameters such as PCT, PLCR, PDW, MPW and PLT. Conclusion: As a further study, it would be beneficial to reveal the reasons for these effects on platelet parameters with more detailed studies.