Coinfection of Ureaplasma urealyticum/Mycoplasma hominis in HPV Positive Women: Frequency, Risk Factors and Multidrug Resistance

OpenAlex İngilizce

Cervical cancer has a significant place worldwide in terms of cancer-related deaths in women. In the development of cervical cancer and its precursor, cervical intraepithelial neoplasia (CIN), the most important reason is high-risk human papillomavirus (HR-HPV) persistence. 1 Factors such as smoking, high-parity, long-term use of oral contraceptives, other sexually transmitted infectious agents and coinfestation are thought to affect the progression to cervical cancer in HPV infected women. The geni-tal mycoplasmas are a class of pathogenic, the smallest free living bacteria in the ciliated epithelial cells of the urinary and genital tract of humans. The genital mycoplasmas colonized in the genital system consist of six types, including Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, Mycoplasma genitalium, Mycoplasma primatum and Mycoplasma spermatophilum. 5 Some studies have shown that the rate of infection of U. urealyticum is high in HPV positive women. Similarly, there are