Makale detayı · 2024
Ginger essential oil-loaded hydrogels: preparation, characterization, cytotoxicity, antimicrobial and anti-inflammatory activity
Journal of Essential Oil Research
- Yıl
- 2024
- ISSN
1041-2905- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
The present study aimed to develop ginger essential oil hydrogel formulations, using sodium carboxymethyl cellulose (Na CMC), Carbopol, and xanthan gum for dental and oromucosal infections. The physicochemical properties of the hydrogels were evaluated, and their bioadhesive characteristics were determined. Antimicrobial activity, cytotoxicity, and lipoxygenase (LOX) inhibitory activities of the essential oil and its formulations were investigated, respectively. The major components of ginger essential oil were confirmed as α-zingiberene (39.0%) and ar-curcumene (23.7%) by GC-FID and GC/MS analyses. The initial results showed that none of the tested gel formulations selected for the application were non-cytotoxic. According to antimicrobial and LOX enzyme activity studies, the essential oil-loaded xanthan gum gel (X3) was more effective compared to the essential oil itself. The initial formulation and biological evaluation studies concluded that ginger essential oil hydrogels (X3, C3) can be further developed for oral and dental health by providing a long residence time due to their bioadhesive properties.
Konular
- Ginger and Zingiberaceae research
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
Birincil konu Ginger and Zingiberaceae research