Is elevated monocyte to high-density lipoprotein ratio a predictor of symptomatic plaque in patients with intermediate carotid artery stenosis?

OpenAlex İngilizce

Aim: Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a new and easily measurable marker positively associated with inflammation. In this study, we aimed to evaluate if there was a relationship between MHR and the risk of presence of symptomatic plaque in patients with intermediate carotid artery stenosis. Materials and Methods: A total of 179 of patients who had 50%-70% stenosis in the carotid artery were included in this retrospective cohort study. Patients were assigned into two groups based on symptomatic (n=104) and asymptomatic (n=75) group. Groups were compared in terms of MHR. Predictive role of MHR for presence of symptomatic plaque was investigated. Results: Monocyte to high-density lipoprotein cholesterol ratio was significantly higher in the symptomatic group (11.40 ± 4.24 vs 18.33 ± 9.06, p < 0.001). Monocyte to high-density lipoprotein cholesterol ratio > 13.48; had 70.19% sensitivity and 76.0% specificity for prediction of symptomatic plaque (AUC: 0.787, 95% CI: 0.720–0.840, p < 0.001) in patients with intermediate carotid artery stenosis. In a univariate analysis age, gender, hemoglobin, neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), smoking, total cholesterol and MHR were significantly associated with presence of symptomatic carotid plaques. Monocyte to high-density lipoprotein cholesterol ratio (OR:1.330, p < 0.001) and hemoglobin (OR:1.441, p = 0.013) were found to be significant independent predictors of symptomatic plaques in the carotid artery in a multivariate analysis, after adjusting for other risk factors. Conclusion: MHR plays a moderate role for prediction of symptomatic plaques in the carotid artery.