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Makale detayı · 2018

Epidemiology of sepsis in intensive care units in Turkey: a multicenter, point-prevalence study

CRITICAL CARE

YÖKSİS OpenAlex Açık erişim · gold SJR Q1 JCR Q1 Atıf 128 Üst %10 Yüzdelik 98.6% FWCI 8.79
Yıl
2018
ISSN
1466-609X
DOI
10.1186/s13054-018-2013-1
Tür
article

Veri kaynağı ayrımı

  • YÖKSİS YÖKSİS makale kaydı
  • OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)

OpenAlex kaydı

Özet

İngilizce (OpenAlex)

BACKGROUND: The prevalence and mortality of sepsis are largely unknown in Turkey, a country with high antibiotic resistance. A national, multicenter, point-prevalence study was conducted to determine the prevalence, causative microorganisms, and outcome of sepsis in intensive care units (ICUs) in Turkey. METHODS: A total of 132 ICUs from 94 hospitals participated. All patients (aged > 18 years) present at the participating ICUs or admitted for any duration within a 24-h period (08:00 on January 27, 2016 to 08:00 on January 28, 2016) were included. The presence of systemic inflammatory response syndrome (SIRS), severe sepsis, and septic shock were assessed and documented based on the consensus criteria of the American College of Chest Physicians and Society of Critical Care Medicine (SEPSIS-I) in infected patients. Patients with septic shock were also assessed using the SEPSIS-III definitions. Data regarding demographics, illness severity, comorbidities, microbiology, therapies, length of stay, and outcomes (dead/alive during 30 days) were recorded. RESULTS: Of the 1499 patients included in the analysis, 237 (15.8%) had infection without SIRS, 163 (10.8%) had infection with SIRS, 260 (17.3%) had severe sepsis without shock, and 203 (13.5%) had septic shock. The mortality rates were higher in patients with severe sepsis (55.7%) and septic shock (70.4%) than those with infection alone (24.8%) and infection + SIRS (31.2%) (p < 0.001). According to SEPSIS-III, 104 (6.9%) patients had septic shock (mortality rate, 75.9%). The respiratory system (71.6%) was the most common site of infection, and Acinetobacter spp. (33.7%) were the most common isolated pathogen. Approximately, 74.9%, 39.1%, and 26.5% of Acinetobacter, Klebsiella, and Pseudomonas spp. isolates, respectively, were carbapenem-resistant, which was not associated with a higher mortality risk. Age, acute physiology and chronic health evaluation II score at ICU admission, sequential organ failure assessment score on study day, solid organ malignancy, presence of severe sepsis or shock, Candida spp. infection, renal replacement treatment, and a nurse-to-patient ratio of 1:4 (compared with a nurse-to-patient ratio of 1:2) were independent predictors of mortality in infected patients. CONCLUSIONS: A high prevalence of sepsis and an unacceptably high mortality rate were observed in Turkish ICUs. Although the prevalence of carbapenem resistance was high in Turkish ICUs, it was not associated with a higher risk for mortality. TRIAL REGISTRATION: ClinicalTrials.gov ID NCT03249246 . Date: August 15, 2017. Retrospectively registered.

Konular

  • Sepsis Diagnosis and Treatment
  • Nosocomial Infections in ICU
  • Intensive Care Unit Cognitive Disorders

Birincil konu Sepsis Diagnosis and Treatment

Yazarlar

  1. ZEHRA NUR BAYKARA
  2. EMİN HALİS AKALIN
  3. MUSTAFA KEMAL ARSLANTAŞ
  4. VOLKAN HANCI
  5. ÇİĞDEM ÇAĞLAYAN
  6. FERDA ŞÖHRET KAHVECİ
  7. KUBİLAY DEMİRAĞ
  8. CANAN BAYDEMİR KOCAELİ ÜNİVERSİTESİ
  9. MUSTAFA NECMETTİN ÜNAL
  10. PINAR ÖZDEMİR
  11. HÜLYA ULUSOY KARADENİZ TEKNİK ÜNİVERSİTESİ
  12. DİLEK MEMİŞ TRAKYA ÜNİVERSİTESİ
  13. MAKBULE CAVİDAN ARAR TEKİRDAĞ NAMIK KEMAL ÜNİVERSİTESİ
  14. ELİF YILMAZ
  15. MELEK GÜRA ÇELİK
  16. İSMAİL HAKKI CİNEL
  17. SİBEL TEMUR
  18. MEHMET AKİF YAŞAR
  19. HAMDİYE TUTAN ÇULHA
  20. CANAN BALCI
  21. SULTAN SAN
  22. ASENA SALBES
  23. ELÇİN ÖZKAN
  24. ONUR PALABIYIK
  25. JALE BENGİ ÇELİK
  26. ALPER YOSUNKAYA NECMETTİN ERBAKAN ÜNİVERSİTESİ
  27. FARUK ÇİÇEKÇİ
  28. IŞIL ÖZKOÇAK TURAN
  29. İSMAİL KATI
  30. HÜLYA BAŞAR
  31. SEMA TURAN
  32. SÜHEYLA ÜNVER
  33. ÜNASE BÜYÜKKOÇAK
  34. AYNUR KARAYOL AKIN
  35. SİNAN GÜRSOY SİVAS CUMHURİYET ÜNİVERSİTESİ
  36. DEMET TOK
  37. SİMAY SERİN
  38. SEDA DURSUN KITER
  39. HAKAN DOĞAN
  40. ABDULKADİR ORUÇ
  41. ONUR BALABAN
  42. DİLARA TÜFEK ÖZTAN
  43. İBRAHİM KURT
  44. MURAT BİLGİ
  45. VERDA TUNA
  46. AYŞEGÜL ÖZKÖK
  47. AHMET ŞEN TRABZON ÜNİVERSİTESİ
  48. NİLAY TAŞ
  49. HİLAL AYOĞLU ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ
  50. BERNA KAYA UĞUR
  51. SEDAT KAYA
  52. MUSTAFA KAHRAMAN
  53. ZAHİDE DOĞANAY
  54. GÖKALP SOYKAM
  55. IŞIL KÖSE
  56. BİRGÜL YELKEN
  57. OSMAN EKİNCİ
  58. GÖNÜL ÖLMEZ KAVAK DİCLE ÜNİVERSİTESİ
  59. UĞUR GÖKTAŞ
  60. TÜRKAN TOGAL
  61. NAZIM DOĞAN
  62. HASAN MURAT GÜNDÜZ ÇUKUROVA ÜNİVERSİTESİ
  63. SELİM TURHANOĞLU HATAY MUSTAFA KEMAL ÜNİVERSİTESİ
  64. ATİLLA RAMAZANOĞLU
  65. FÜSUN KOZANLIOĞLU
  66. ŞABAN YALÇIN
  67. HATİCE YAĞMURDUR
  68. ATİLLA TUTAK
  69. ALİ AYDIN ALTUNKAN MERSİN ÜNİVERSİTESİ
  70. UFUK KUYRUKLUYILDIZ
  71. GÜLSÜM OYA HERGÜNSEL
  72. KEREM ERKALP
  73. ALİ NECATİ GÖKMEN DOKUZ EYLÜL ÜNİVERSİTESİ
  74. MURAT AKSUN
  75. HALİL ERKAN SAYAN
  76. ONUR ÖZLÜ
  77. YAVUZ DEMİRARAN
  78. EVREN ŞENTÜRK
  79. IŞIN GENÇAY
  80. HAFİZE ÖKSÜZ
  81. NİHAN YAPICI
  82. ARAŞ PİRAT
  83. TUĞHAN UTKU
  84. ENDER GEDİK
  85. ORHAN BEHRET
  86. KADİR İDİN
  87. HAYRETTİN DAŞKAYA
  88. FİLİZ BANU ETHEMOĞLU
  89. ALİ ALAGÖZ
  90. SEVAL İZDEŞ
  91. MUSTAFA KEMAL BAYAR
  92. NERMİN KELEBEK GİRGİN
  93. LALE KARABIYIK
  94. UĞUR KOCA
  95. NURCAN ÇUBUKÇU
  96. FATMA ÜLGER ONDOKUZ MAYIS ÜNİVERSİTESİ
  97. ŞEYDA EFSUN ÖZGÜNAY
  98. PERİHAN ERGİN ÖZCAN
  99. BAŞAR ERDİVANLI
  100. ŞENAY GÖKSU TOMRUK
  101. ABBAS KÖSE
  102. RAFİ DOĞAN
  103. GÜLDEM TURAN
  104. OSMAN ARPAZ
  105. ALİYE ESMAOĞLU
  106. MUSA SALMANOĞLU
  107. ÖZGÜR CANOLER
  108. NEDİM ÇEKMEN
  109. CANAN KANDAZ
  110. GÜLŞEN BULUT KAYA
  111. MELİS DÜLGEROĞLU
  112. İLKNUR ŞEKER
  113. AYSU HAYRİYE TEZCAN
  114. HALİL İBRAHİM UZUNLAR
  115. MEHMET AKİF YAZAR
  116. REYHAN ARSLANTAŞ
  117. NALAN ADIGÜZEL
  118. OKAY ÖZTÜRK
  119. ZAKİR ARSLAN
  120. ÖZGÜR ÖZMEN
  121. GÜNSELİ ORHUN
  122. EVREN BÜYÜKFIRAT HARRAN ÜNİVERSİTESİ
  123. OYA ÇİMEN BUDUR
  124. MEHMET ERDEM AKÇAY
  125. ASU ÖZGÜLTEKİN
  126. ERTUĞRUL KILIÇ
  127. MAKBULE ELİF YILMAZ
  128. ÖMÜR İLBAN
  129. FEYZA KARGIN
  130. MEHMET MURAT SAYIN
  131. RESUL ALTUNTAŞ
  132. BERNA ÇALIŞKAN
  133. AYŞEN ERDOĞAN
  134. VOLKAN ALPARSLAN
  135. MURAT TEKİN