Makale detayı · 2024
Joint by Joint Correlations Between Ultrasound HEAD-US Scores and HJHS Joint Scores in Hemophilia A Patients: A National, Multi-Center, Prospective, and Cross-Sectional Study
Turkiye Klinikleri Journal of Medical Sciences Journal
- Yıl
- 2024
- ISSN
2146-9040- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Objective: Hemophilia Joint Health Score (HJHS) and Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) Score are indispensable tools for the routine evaluation of joint health in individuals with hemophilia A. This study aims to meticulously evaluate the joint-specific correlations between the HJHS and HEAD-US scoring systems in hemophilia A patients, focusing on the elbow, knee, and ankle joints. Material and Methods: A comprehensive national, multicenter, prospective, cross-sectional, non-interventional observational study was conducted across 19 medical centers in Türkiye, involving 192 hemophilia A patients over a two-year duration. The inclusion criteria encompassed patients aged ≥6 years with moderate or severe hemophilia A (FVIII<2%), comprising 63.5% pediatric and 36.5% adult patients. Results: In the analysis of 192 patients under prophylactic treatment, a robust correlation was identified between the HJHS and HEAD-US total scores across all age groups. Particularly noteworthy was the finding that adults exhibited a more pronounced correlation than their pediatric counterparts for total scores. When exploring the correlation among the six joints, it became apparent that elbows exhibited the highest correlation (r: 0.408/0.581), while ankles demonstrated the lowest correlation (r: 0.397/0.311). Furthermore, the study uncovered an intriguing insight: a significant difference in correlation rates between children and adults, adding a layer of complexity to the joint evaluation process. Conclusion: The HEAD-US and HJHS scoring systems serve as valuable monitoring tools in hemophilia A, offering complementary insights. Our findings highlight varying correlation rates among joints, emphasizing elbows as the most correlated joints.
Konular
- Hemophilia Treatment and Research
Birincil konu Hemophilia Treatment and Research