Proconvulsant effect of papaverine on penicillin-induced epileptiform activity in rats

İngilizce (OpenAlex)

vasospasm, the causes of which include vasospasm, microvascular deficit and cortical spreading depression (18).The exact cause of post-hemorrhagic constriction in cerebral arteries is not known.There are many factors known to cause vasospasm, such as structural changes in the cells of the arterial wall, erythrocyte breakdown products, serum lipids and some plasma proteins.These causes probably initiate a series of chain reactions leading to vasospasm (16). █ INTRODUCTION Vasospasm that develops following aneurysmal subarachnoid hemorrhage is a serious condition causing mortality and permanent damage.Angiographic vasospasm develops in about 70% of patients with aneurysmal subarachnoid hemorrhage.This reversible vasospasm generally occurs between the 3 rd and 14 th days (6,9,16).About 30% of these patients develop late ischemic deficit, symptomatic AIM: Papaverine is a vasodilator agent that is an opium alkaloid.It exhibits its effects by inhibiting the phosphodiesterase enzyme.Papaverine administration is widely used to avoid symptomatic vasospasm after subarachnoid hemorrhage.We aimed, in this research, to study the effects of papaverine on the epileptic discharges stimulated by penicillin.MATERIAL and METHODS: Adult female Wistar rats (220±30 g) were included in this research (n=30).Rats were anesthetized with urethane (1.25 g/kg) and then the left cerebral cortex was reached by opening a burr hole with a drill.Penicillin G sodium salt (500 IU)(200 IU/1 μl) was injected into the left lateral ventricle to produce epileptiform activity.Thirty minutes before penicillin G sodium injection, papaverine was administered at doses of 5, 10, 20 or 40 mg/kg intraperitoneally. RESULTS:There was no significant difference in spike frequency between the control group and the groups given 5 mg/kg, 10 mg/ kg or 40 mg/kg papaverine, while 20 mg/kg papaverine significantly increased the spike frequency (p<0.05). CONCLUSION:Papaverine augments the epileptiform activity produced by penicillin injection.It is important to remember that papaverine might induce convulsions in patients who have epilepsy.More research is required to understand the mechanisms of the proconvulsant influence of papaverine in epilepsy.