Glyceryl trinitrate for the treatment of preterm labor

İngilizce (OpenAlex)

Study participantsIn total, 48 women from 27 0/7 weeks to 34 0/7 weeks of gestation who were in threatened preterm labor were randomly allocated to receive either GTN (n=25) or MgSO 4 (n=23) tocolysis, and the control group consisted of 25 pregnant women who were between the same gestational age and had no signs of threatened preterm labor.Preterm labor was defined as the clinical diagnosis of at least two painful, regular uterine contractions every 10 minutes and evidence of cervical change (change in Bishop score or Bishop score>6).Inclusion criteria were single pregnancyObjective: This study was conducted to compare the tocolytic efficacy of glyceryltrinitrate (GTN) with that of magnesium sulfate (MgSO4) and to investigate serum nitric oxide metabolites before and after tocolysis. Material and Methods:In total, 48 women between 27 and 34 weeks' gestation with threatened preterm labor and intact membranes were randomly allocated to receive either GTN or MgSO 4 tocolysis.Main outcome measures included tocolytic efficacy and maternal side effect(s) of the tocolytic agent.Obstetric and neonatal outcomes as well as pretreatment and posttreatment nitric oxide (NO) metabolites were assessed.Results: Forty-one patients were included into the final analysis.Uterine contraction cessation times were 3.66±1.28and 6.83±3.47hours for GTN and MgSO4 groups, respectively.Similarly, maternal side effects were significantly lower in the GTN group than in the MgSO4 group, and no serious maternal side effects were recorded.Serum NO metabolite levels before treatment were significantly lower in the treatment groups than in the controls.Serum nitrite levels were significantly increased after tocolytic treatment both in MgSO 4 and GTN groups.Conclusion: GTN effectively delays preterm delivery and reduces neonatal morbidity and mortality with less maternal side effects and seems to be an effective and safe alternative to MgSO 4 .(