Makale detayı · 2016
Extensive Gray Matter Volume Reduction and Correlations with Neuropsychological Performance in Alcohol Use Disorder Patients
Dergi
KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGYISSN 1017-7833
ISSN kaydı başka bir dergiye işaret ediyor; ad YÖKSİS kaydından.
- Yıl
- 2016
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
- Katalog eşleşmesi (ISSN) Klinik Psikofarmakoloji Bulteni
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Objective: Long term alcohol use results in varying degrees of deficits in cognitive functions. Although the neocortex, particularly the frontal lobe; limbic system and cerebellum are the brain regions most vulnerable to the toxic effects of alcohol, neural correlates of neuropsychological deficits have not been studied directly.Methods: This voxel based morphometric (VBM) study examined the effect of duration and amount of alcohol exposure on gray matter (GM) volume and the relation between GM volumes and neuropsychological deficits in patients with Alcohol Use Disorder (AUD).Results: Voxel-wise whole brain analysis showed extensive regional gray matter volume for AUD patients and GM volumes were inversely correlated to the amount of alcohol exposure. More importantly, there were statistically significant correlations between different indices of executive functioning and GM volumes.Conclusion: These results indicate that dose-dependent alcohol effect on prefrontostriatal and temporal circuitries appears to be directly related to neurocognitive deficits seen in these patients.
Konular
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
Birincil konu Neurotransmitter Receptor Influence on Behavior