Makale detayı · 2015
Enantiospecific Synthesis of R 3 Amino 4 2 4 5 trifluorophenyl butanoic Acid Using S Serine as a Chiral Pool
YÖKSİS
OpenAlex
SJR Q2
JCR Q3
Atıf 3
Yüzdelik 56.3%
FWCI 0.16
- Yıl
- 2015
- ISSN
0018-019X- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Abstract Starting from (S)‐serine, a new method was developed for the synthesis of the β‐amino acid part of sitagliptin in ten steps and with an overall yield of 30%. The crucial step of the synthesis was the ring opening of N‐ and O‐protected (R)‐aziridin‐2‐methanol with (2,4,5‐trifluorophenyl)magnesium bromide to give N‐ and O‐protected (R)‐2‐amino‐3‐(2,4,5‐trifluorophenyl)propan‐1‐ol.
Konular
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
Birincil konu Synthesis and Catalytic Reactions