Evaluation of the Appropriateness of Fresh Frozen Plasma Indications and Cost Analysis: A Comprehensive Study

OpenAlex İngilizce

Amaç: Taze donmuş plazma (TDP) sık kullanılmasına rağmen sınırlı endikasyona sahiptir.Bu çalışmanın amacı TDP transfüzyonu yapılan hastaların klinik ve laboratuvar bulgularını araştırmaktır.Ayrıca transfüzyonun uygunluğu ve etkinliği de incelenmiştir.Yöntem: Herhangi bir nedenle TDP transfüzyonu yapılan 18 yaş altı hastaların dosyaları retrospektif olarak incelendi.Transfüzyon uygunluğu transfüzyon kılavuzuna göre belirlendi.Bulgular: Çalışmaya 134 hastaya yapılan iki yüz sekiz TDP transfüzyonu dahil edildi.Toplam 429 ünite TDP transfüzyonu yapıldı.Yapılan 208 transfüzyonun 156'sı (%75) endikasyonlara göre uygunken, 52'si (%25) uygunsuz olarak değerlendirildi.Toplam 429 ünite ürünün 87'si (%20,2) uygunsuz olarak transfüzeObjective: Fresh frozen plasma (FFP) has limited indications despite its frequent use.This study aimed to investigate the clinical and laboratory findings of patients who received FFP transfusion.The suitability and effectiveness of transfusion were also examined. Methods:We retrospectively reviewed the files of patients who underwent FFP transfusion for any reason below the age of 18 years.Transfusion suitability was determined based on the transfusion guidelines.Results: Two hundred eight FFP transfusions to 134 patients were included in the study.In total, 429 units of FFP were transfused.Of the 208 transfusions, 156 (75%) were appropriate based on indication and 52 (25%) were considered inappropriate.In total, 87 out of the 429 units of the product (20.2%)were transfused inappropriately.None of the patients who received inappropriate transfusions exhibited signs of bleeding.Significant improvements in prothrombin time and activated partial thromboplastin time were observed in patients who received transfusions with appropriate indications. Conclusion:In this study, the incidence of inappropriate FFP transfusion was lower compared to other centers.However, 3 out of 4 patients received prophylactic FFP for bleeding prevention.The cost of inappropriate transfusions in this study was estimated at $1640 annually.Since transfusion practices are mostly based on adult studies, our study will increase awareness regarding transfusion practices among children.Consequently, there is a need for educational programs that can reduce the rate of FFP transfusions.