Makale detayı · 2017
Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean platelet volume and plateletcrit in isolated intrauterine growth restriction and prediction of being born small for gestational age
Archives of Medical Science - Civilization Diseases
- Yıl
- 2017
- ISSN
2451-0637- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Introduction: Mean platelet volume (MPV), plateletcrit (PCT), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are accepted as inflammatory markers. In this study, we aimed to investigate the changes occurring in these parameters in pregnancies complicated with intrauterine growth restriction (IUGR) and the role of these parameters in the prediction of being born small for gestational age (SGA). Material and methods: The study concerned a group of 200 patients with isolated IUGR and a control group of 200 patients without IUGR. Changes in MPV, PCT, NLR, and PLR were analyzed in patients with IUGR and prediction of SGA. Results: Gravida, parity, gestational week at birth, and birth weight were significantly lower in the IUGR group. The PCT and MPV values were similar in both groups. Lymphocyte count was significantly higher and the PLR and NLR values were significantly lower in the IUGR group. In the ROC curve analysis, the area under the curve (AUC) values for NLR, PLR, and lymphocyte count were statistically significant (p = 0.005, 0.0001, 0.0001, respectively). Conclusions: The NLR, PLR, and lymphocyte count appear to be useful markers for the prediction of SGA newborns. However, their low sensitivity and specificity values restrict their use in clinical practice.
Konular
- Pregnancy and preeclampsia studies
- Inflammatory Biomarkers in Disease Prognosis
- Birth, Development, and Health
Birincil konu Pregnancy and preeclampsia studies