The Investigation of Chlamydia trachomatis and Ureaplasma urealyticum Coinfections in HPV Positive and HPV Negative Women

OpenAlex İngilizce

Introduction: Human papillomavirus (HPV) is the primary cause of cervical cancer. Chlamydia trachomatis together with HPV is a potential cofactor for the development of cervical intraepithelial neoplasia. Ureaplasma urealyticum, which is found commensally in the urogenital region, is considered to contribute to urogenital infections. The aim of this study was to investigate C. trachomatis and U. urealyticum coinfections in HPV positive and HPV negative women. \n \nMaterials and Methods: Cervical swab samples were collected from 300 females aged 20-65 years. Real-time PCR (Anatolia Geneworks, Turkey) test was used for HPV genotyping. C. trachomatis and U. urealyticum infections were detected by in-house PCR in HPV positive (n= 200) and HPV negative (n= 100) women. \n \nResults: HPV 16 (53%) was the most dominant HPV genotype in 200 HPV positive women, followed by HPV 18 (30%), HPV 68 (10.5%), HPV 56 (10%), HPV 45 (9%), HPV 52 (6%), HPV 39 and HPV 51 (5%), HPV 66 (3.5%), HPV 35 and HPV 58 (2.5%), and HPV 33 (1.5%). C. trachomatis and U. urealyticum were detected to be 22 (11%) and 61 (30.5%), respectively in HPV positive women, while it was found to be 8 (8%) and 23 (23%), respectively in HPV negative women. C. trachomatis and U. urealyticum coinfection was found in 1.5% (3/200) of HPV positive women and 4% (4/100) of HPV negative women. \n \nConclusion: C. trachomatis and U. urealyticum coinfection was found at a relatively high rate in high-risk HPV positive female patients. In order to understand the role of coinfections in cervical cancer pathogenesis, further studies including a control group may be instructive.